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All four trials were randomized, double-blind, placebo-controlled, parallel-group studies examining the use of topiramate in migraine prevention.
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McCall et al (1995) have highlighted the increased risk of death due to pulmonary embolism in patients with persistent catatonia; such deaths occurred only after the second week of catatonia, often without warning.
For Borderline Personality Disorder: "Personally this drug helped my mood swings greatly, however I was quite disturbed that it agitated my diet as much as it did.
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Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice.
Neurotransmitters and biochemical factors may sensitize neural elements in the motion segment so that the normal biomechanical stresses induced by previously asymptomatic movements or lifting tasks cause pain.
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Patients were given a 10-question Amphetamine Withdrawal Questionnaire modified for phentermine while they were taking the drug, and then again for the next 2 days when the drug was withheld.
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Each patient was followed for 12 weeks and was assessed at entrance, in the fourth week and twelfth week for frequency of attacks, headache severity, need for acute medication, migraine disability assessment score, and adverse effects.
N90157--------Mean Dose8200--------Median Dose8200--------In all add-on trials, the reduction in seizure rate from baseline during the entire double-blind phase was measured.
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Topiramate is used by healthcare practitioners alone or with the help of other medications to control and prevent seizures in patients that have this condition.
Similar GABA-enhancing antiepileptic drugs were shown to be effective in reducing aggression in prisoners with personality disorders ().
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If you take too much Qsymia, call your healthcare provider or go to the nearest emergency room right away.
As well as its needed effects, topiramate may cause unwanted side effects that require medical attention.
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Safety and effectiveness in patients below the age of 2 years have not been established for the monotherapy treatment of epilepsy.
Metformin is contraindicated with metabolic acidosis, a possible effect of topiramate (7.
Similarly, in the BLOSSOM (Behavioral Modification and Lorcaserin Second Study) trial, mean weight loss was -2.
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The effectiveness of topiramate as an adjunctive treatment for primary generalized tonic-clonic seizures in patients 2 years old and older was established in a multicenter, randomized, double-blind, placebo-controlled trial, (Study YTC), comparing a single dosage of topiramate and placebo (see Table 15).
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Many believe that a shorter period of seizure activity causes neuronal injury and that seizure self-termination is unlikely after 5 minutes.
Most studies included various types of physiotherapy including exercise, massage, electrotherapy, thermotherapy, and other modalities, which makes it difficult to evaluate the effectiveness of back schools alone.
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Topamax should be used with extreme caution in children for migraines and in children younger than 2 years old for seizures; safety and effectiveness in these children have not been confirmed.
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This study is working to identify risk factors for birth defects and to answer questions about some medications taken during pregnancy.
Data show that a fetus exposed to topiramate, a component of Qsymia, in the first trimester of pregnancy has an increased risk of oral clefts (cleft lip with or without cleft palate).
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