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Diagnostic algorithms, monitoring, prognostication, and therapy in chronic myeloid leukemia (CML): a proposal of the Austrian CML platform.

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Second-line treatments after first-line gefitinib therapy in advanced nonsmall cell lung cancer.

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Antiangiogenic therapy is very expensive and potentially toxic even in carefully selected patients; hence, a detailed discussion with patients about its modest benefits versus the risks and costs is important.

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Untreated VACV infectedcells and uninfected cells are shown as controls in the right panel.

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Accordingly, the development of a new EGFR TKI without adverse events of interstitial lung diseases or the discovery of predictive factors of intestinal lung disease is expected.

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Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain.

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Disclaimer: The materials published on the Clinical Care Options Sites reflect the views of the reviewers or authors of the CCO material, not those of Clinical Care Options, LLC, the accredited provider, or the companies providing educational grants.

Transesophageal endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) biopsy: a combined approach in the evaluation of mediastinal lesions.

Cancer cells were seeded in 96-well plates and were treated with different doses of gefitinib, metformin or both for 72 hours.

But Owing to the paucity of current data on gefitinib between defferent races, the possibility of differences in the toxicity and efficacy of gefitinib for ethnicity cannot be excluded.

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Effect of epidermal growth factor receptor tyrosine kinase domain mutations on the outcome of patients with non-small cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors.

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Evaluation of biologic end points and pharmacokinetics in patients with metastatic breast cancer after treatment with erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor.

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Three Cases of Non-Small Cell Lung Cancer, Which Simultaneously Expressed Activating Epidermal Growth Factor Receptor (EGFR) Mutations and EGFR-Tyrosine Kinase Inhibitor (TKI) Resistance Mutations (T790M) Before Gefitinib Therapy.

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Randomized phase II study of gefitinib versus erlotinib in patients with advanced non-small cell lung cancer who failed previous chemotherapy.

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In EGFR-mutated patients with acquired resistance to either gefitinib or erlotinib continued EGFR inhibition might be clinically beneficial, akin to the continued blockage of ErbB2 (HER2) with trastuzumab in ErbB2-amplified breast cancers.

Rozen SM, Nahabedian MY, Manson PN: Management strategies for pyoderma gangrenosum: case studies and review of literature.

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One issue with delaying second-line therapy has been the "drop-off" of patients who never get second-line therapy presumably due to disease-related complications and erosion of their performance status (PS) precluding subsequent therapy.

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