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DHT is no longer functioning in those tissues where it was inhibited by the drug.
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Nevertheless, it is understood that androgens, growth factors, neurotransmitters and other cell interactions play a role in the development of this condition.
Finasteride tablets USP, 5 mg may also be used to reduce the risk of a sudden inability to pass urine and the need for surgery related to BPH in men with an enlarged prostate.
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After a two-week period during which the men received a placebo in single-blind fashion, they were randomly assigned in a double-blind fashion to one of three treatment groups: 297 were assigned to receive a 5-mg tablet of finasteride daily, 298 to receive a 1-mg tablet of finasteride daily, and 300 to receive a placebo tablet each day.
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This enzyme converts excess testosterone into its more androgenic brother, dihydrotestosterone (DHT).
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Finasteride does not inhibit 5AR-I anywhere near to the same extent as 5AR-II).
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Finasteride improves symptoms of such as frequent and difficult urination and may reduce the chance of acute urinary retention.
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While transrectal ultrasound and digital rectal exam were used to evaluate prostate volume, the Sexual Function Inventory Questionnaire and the Short Form-36 Health Survey were used to evaluate sexual function and quality of life, respectively.
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