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Recently, a large randomized trial in type 1 diabetic patients with nocturnal hypoglycemia reported that sensor-augmented insulin pump therapy with the threshold-suspend feature reduced nocturnal hypoglycemia, without increasing glycated hemoglobin values ().

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This study was not designed to compare treatment groups for infrequent events.

Ezetimibe is rapidly metabolized to ezetimibe-glucuronide in humans.

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In terms of elevations in liver function tests, ezetimibe appears to cause similar elevations in transaminases (three times the upper limit of normal with alanine transaminase or aspartate transaminase) as compared to placebo when given as monotherapy.

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Blending of ezetimibe with starch alone results in some agglomeration of ezetimibe ( FIG.

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Ezetimibe is a cholesterol-lowering drug that inhibits intestinal absorption of cholesterol and structurally related plant sterols across the intestinal wall.

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High-risk patients who might benefit from additional LDL-C lowering include those with clinical atherosclerotic CV disease, genetic hypercholesterolemia, or diabetes who are statin intolerant or who did not achieve at least a 50% LDL-C reduction with the maximally tolerated intensity of statin therapy.

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