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Still further examples can include two differently charged ions each with similar uses but with different mechanisms of action.
In addition, none of the treatments resulted in physical discomfort (Q 6).
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Atorvastatin, sold under the trade name LIPITORTm, and pravastatin, sold under the trade name PRAVACHOLTm, are used to treat cholesterol and are further examples of suitable compounds that can be used to prepare the disclosed ionic liquid compositions.
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Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic.
The kit comprises: (a) CNS active agent in pharmaceutical compatible excipient; (b) hypertensive agent in pharmaceutical compatible excipient; and (c) instructions (e.
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From Martindale, The Extra Pharmacopoeia, 30th ed, p825) Indication: For use in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.
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It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome.
Strong Lewis Acid-Lewis Base Interactions between Supercritical Carbon Dioxide and Carboxylic Acids: Effects on Self-association.
Thus, it is not possible to specify an exact "effective amount.
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Thus it is formed a "defective" viral DNA which leads to suppression of replication of new generations of viruses.
Department of Health and Human Services, FDA, 2004).
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Cyclobenzaprine is structurally related to the tricycle antidepressant amitriptyline but is not clinically used as an antidepressant.
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As such, these methods can be used with the disclosed ionic liquid compositions to produce controlled release vehicles that can release the disclosed ionic liquid composition with a desired release profile.
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This drug would be comparable to benzodiazepines, but lacking their limiting side effects at therapeutic doses.
Throughout the specification "alkyl" is generally used to refer to both unsubstituted alkyl groups and substituted alkyl groups; however, substituted alkyl groups are also specifically referred to herein by identifying the specific substituent(s) on the alkyl group.
Maudsley Prescribing Guidelines in Psychiatry (11th ed.
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Selegiline is used to treat Parkinson's disease, a disease associated with low levels of dopamine in your brain.
When used along with the neuromodulators of the present invention, lower therapeutically effective dosages may be achieved.
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CNS) active agent, comprising: administering to a patient between about 5 to about 80 percent of the conventionally accepted effective dosage of the addictive CNS active agent, the CNS active agent having a time to maximum concentration (Tmax); and administering to the patient at least two vagal neuromodulators in an amount sufficient to reduce the dosage of the addictive CNS active agent without reduction of efficacy, the at least two vagal neuromodulators comprising a mechanoreceptor stimulator and a chemoreceptor stimulator, the mechanoreceptor being released or administered after the CNS active agent.
This can take the form of either a discrete pellet or granule that is mixed in with, or compressed with, the other three components.
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One or more types of dialiphatic dialkyl ammonium cations can be used in the ionic liquid compositions disclosed herein.
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The mechanism of action is associated with selective blockade of the inverse of neuronal serotonin reuptake in the CNS.
Other delayed gastric-emptying approaches may be used in order to delay the release of vagal neuromodulators in the stomach.
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The method as recited in claim 16, wherein the method effects a decreased metabolism of the compound per dosage unit thereof by at least one polymorphically-expressed cytochrome P 450 isoform in the subject, as compared to the corresponding non-isotopically enriched compound.
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According to the methods and compositions disclosed herein, ion identification and combination, as disclosed herein, can involve any ion, not just ionic drugs, as long as the combination results in an ionic liquid.
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Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease).
Indication: For use as an adjunct to diet for the control of hyperglycemia and its associated symptomatology in patients with non-insulin-dependent diabetes mellitus (NIDDM; type II), formerly known as maturity-onset diabetes, after an adequate trial of dietary therapy has proved unsatisfactory.
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The term "sulfoxide" as used herein is represented by the formula A1S(O)A2, where Al and AZ can be, independently, an alkyl, halogenated alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl group described above.
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To introduce deuterium at one or more positions of R 16-R 17 and R 25-R 27, compound 12 with the corresponding deuterium substitutions can be used.
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The disclosed ionic liquid compositions having hydrophobic ions can be particularly useful in such applications because they can adhere to the surface longer when exposed to water or other fluids than would a similar hydrophilic salt.
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For example, the disclosed ionic liquids can be used to dissolve a particular nonionic or ionic pharmaceutical active.
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In other example, the disclosed ionic liquid compositions can be liquid over at least about a 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or more degree temperature range.
Drugs and the Plaarmaceutical Sciences, Marcel Dekker, Inc.
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The presence of bromide anions was monitored by silver nitrate test.
The term “anion precursor” is used herein to specifically refer to a molecule that can be converted to an anion via a chemical reaction (e.
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Preferred unit dosage formulations are those containing an effective dose, as herein below recited, or an appropriate fraction thereof, of the active ingredient.
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Other embodiments provide methods for treating a dopamine receptor-mediated disorder in a patient in need of such treatment, comprising administering to said patient a therapeutically effective amount of a compound or composition according to the present invention.
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Pregabalin is somewhat like Phenibut in effect (as it raises GABA levels) and can be taken with SSRI's.
Which of the following disease would Probanthine exert the much needed action for control or treatment of the disorder?
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Olanzapine may also be used for purposes not listed in this medication guide.
Hydrochlorothiazide is a "water pill" (diuretic) that causes you to make more urine, which helps your body get rid of extra salt and water.
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A4a are used herein as generic symbols to represent various specific substituents.
Side effects may occur.
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This drug may also be used with other medications.
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This medication is active against Candida, Microsporum, Cryptococcus neoformans, Trichophyton.
The finding may enable researchers to use the trio of genes to encourage insulin production in stem cells or other cells that dont normally make insulin. Those cells could be transplanted into the pancreases of people with Type I diabetes.
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This use can provide a slow release form of the API in the ionic liquid or impart a desirable barrier on the area of interest.
You will need to discuss the benefits and risks of using Dostinex while you are pregnant.
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Having described the ingredients and formulations of embodiments of the pharmaceutical composition of the present invention, method(s) of treating humans will now be described, of advantage to provide a CNS active agent (for example, a benzodiazepine) combined with at least one neuromodulator, in a dosage form that delivers the required therapeutic amount of the drug in vivo, and that renders the CNS active agent bioavailable in a constant manner.
The composition of claim 31, wherein the at least one kind of cation comprises the cation of 2-aminothiazole, 6-azauridine, 6-mercaptopurine, 9-aminocamptothecin, acetarsone, acetazolamide, acetosulfone, acetylcysteine, acetylpheneturide, acranil, acrivastine, adrenalone, albutoin, aldioxa, alibendol, alizapride, alkofanone, allopurinol, ambenonium, ambroxol, ambutonium, amexinium, aminitrozole, amiphenazole, amisulpride, anagrelide, arsanilate, arshpenamine, asoxime, azidamfenicol, benfluorex, benfunolol, benserazide, benzaepril, benzilonium, benznidazole, benzoxonium, benzoylpas, berberine, bibenzonium, brequinar, brodimoprim, bromhexine, bromopride, bromo-salicylchloranilide, bucillamine, buformin, bufuralol, bumadizon, bunitrolol, buthalital, cabergoline, carbachol, carbarsone, carbidopa, cariporide, carnitine, caroxazone, celecoxib, cephaeline, cetalkonium, chloguanide, chloramphenicol, chlordantoin, chlorisonclamine, chloroquine, cholic acid, choline, ciclonicate, cilostazol, cimetidine, cinepazide, cinitapride, cisapride, clanobutin, clometocillin, clomiphene, cloricromen, clortermine, cyamelide, cyclazocine, dapsone, dimefline, diphetarsone, distigmine, dithiazanine, donepezil, dopamine, echothiophate, edrophonium, efavirenz, elfornithine, enfenamic acid, etifoxine, etodroxizine, fampridine, fazadinium, fendiline, fenproporex, finasteride, flufenamic acid, flumethiazide, fluoxetine, flurazepam, flutamide, fomepizole, fominoben, hexafluorenium, hydroxystilbamidine, ibudilast, indalpine, indeloxazine, ipratropium, irsogladine, isobutyl p-aminobenzoate, isoetharine, levosimendan, lisuride, lodoxamide, mesalamine, mesoxalate, metformin, methionine, methoxyphenamine, methyl hexaneamine, methylene blue, methylthiouracil, metrons, metyrosine, minoxidil, nadoxolol, nafronyl, naphazoline, naratriptan, neostigmine, nicametate, niclosamide, nicorandil, nilutamide, niridazole, nitazoxanide, nordefrin, obidoxime, omapatrilat, orotic acid, oxaceprol, oxitropium, ozagrel, pamidronic acid, p-aminobenzoic acid, p-aminopropiophenon, pelletierine, pemoline, penicillamine, pentamethonium, pentamidine, pentoxifylline, pergolid, perhexiline, phenmetrazine, phentolamine, phenylephrine, picotamide, pidotimod, pimobendan, pinacidil, pramipexole, prenylamine, prinomastat, pyridinol carbamate, pyridoxine, pyrimethamine, ramatroban, remoxipride, repinotan, riluzole, ritodrine, succinimide, succinylcholine, sulfamethoxazole, sulfapyridine, sulpiride, synephrine, tamsulosin, tedisamil, tenuazonic acid, terazosin, terbutaline, tetrazepam, tetroxoprim, thiabendazole, thiamine, thiopental, tiapride, timonacid, tiopronin, tiotropium, tizanidine, tolazoline, tropicamide, valnoctamide, zafirlukast, or a cationic derivative thereof.
If you think you may be pregnant, contact your doctor so that a pregnancy test can be arranged.
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Unlike most classical antihistamines (histamine H1 antagonists) it lacks central nervous system depressing effects such as drowsiness.
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For example, the first dosage form compartment would initiate release within 1 to four hours after administration of the product.
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